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Data availability The datasets utilized and/or analyzed in this study are available from the corresponding author upon reasonable request

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Ongoing research is examining several important questions regarding tirzepatide's long-term safety profile: Thyroid cancer surveillance : Prospective monitoring of thyroid-related adverse events in large patient cohorts Pancreatic safety : Evaluation of pancreatitis and pancreatic cancer risk with extended exposure Gallbladder disease : Assessment of cholecystitis and cholelithiasis incidence with rapid weight loss Comparative safety : Head-to-head comparisons with other incretin-based therapies The American Diabetes Association and American Association of Clinical Endocrinology (AACE) continue to recommend tirzepatide as an effective treatment option for type 2 diabetes and obesity, with the understanding that ongoing surveillance will further clarify its long-term safety profile